Signal is designed to target metabolic aging at the cellular level by elevating levels of a key metabolite, NAD+, which declines universally with age, and by activating processes involved in supporting mitochondrial health.

Metabolic aging is the imbalance or dysregulation of our metabolism as a function of aging. As we age, levels of NAD+ decline dramatically. NAD+ is a key metabolite whose levels are closely monitored by the cell in order to tune and balance its metabolic reactions. Regulating the vast number of metabolic reactions to maintain balance or homeostasis between energy production and usage is critical for cell health. In addition to the decline in NAD+ level, the activity and levels of sirtuins (NAD+-dependent enzymes involved in regulating metabolism and maintaining energy homeostasis) also decline, further exacerbating the situation. The ingredients in Signal are designed to work synergistically to promote metabolic balance and health by elevating NAD+ levels and activating sirtuin 3.

SIRT3 or sirtuin 3 is a member of the sirtuin family of enzymes that depend on NAD+ to function. SIRT3 enzymes reside in mitochondria and play an essential role in maintaining mitochondrial health and metabolic control, including glucose metabolism, cellular energy (ATP) production, fatty acid oxidation, ketone production during fasting, and amino acid cycling. Mitochondria are central hubs for metabolic reactions and produce ~95% of the cell’s energy. As we age, mitochondrial function and levels of mitochondrial sirtuins decline, leading to metabolic dysregulation. Signal is designed to activate SIRT3 and thus promote mitochondrial and metabolic health.

There are an increasing number of human clinical trials showing benefits of NMN supplementation in supporting aerobic capacity (when combined with exercise) which is important for physical endurance, and maintaining healthy muscle insulin sensitivity in prediabetic women. As more clinical data is available, we look forward to sharing additional information about the benefits of NMN supplementation. There are also a number of pilot studies in humans on honokiol demonstrating potential health benefits. Visit our Science Behind Signal page to find the reference list for these studies.

There is preclinical evidence for potential tissue-specificity between the two different NAD+ precursors in Basis and Signal. More research is needed to support this finding but taking both Basis and Signal may help ensure that NAD+ levels are elevated across a broader range of tissues. In addition, the secondary ingredients in Signal and Basis target different processes in your cells–Signal activates an enzyme that’s involved in mitochondrial function and biogenesis whereas Basis activates an enzyme that is involved in regulating gene expression. We believe that taking both products can lead to a more comprehensive approach to targeting different aspects of aging that includes cellular and metabolic aging.

Our prepaid subscription plans are our most cost-effective options. When you select a semi-annual or annual plan, the pricing offers a savings to customers who commit to a long-term subscription. The longer the commitment, the greater the savings: Starting from $64/bottle for a 1-year (annual) subscription and $72/bottle for a 6-month (semi-annual) subscription. These prepaid subscriptions are considered final sale, so if you cancel in the middle of a 6-month or 1-year plan, you will continue to receive the remaining bottles, and the cancellation will take effect at the end of your plan before renewal. You can also place a single-purchase order by selecting “Individual Purchase” on the checkout page for $190. Please contact our Customer Experience Team at care@elysiumhealth.com if you need to talk about your plan.

Basis, Signal, Matter, Format and Mosaic are available in the United States and Canada. Index is currently only available to ship and bill to addresses located in the U.S.Sign up for our newsletterto be notified of updates related to the international availability of our products.

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All Elysium products can be purchased directly through our website and are not currently available in any retail stores. Signal, Matter, Format, and Index are currently only available for purchase to addresses that bill and ship in the United States. Basis is available for purchase in the United States and Canada. To stay up to date on the international availability of our products, please subscribe to our newsletter.